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In somatic cells, however, hTERT transcription is suppressed through a combination of epigenetic silencing (promoter methylation, histone deacetylation) and transcriptional repressors including Sp3, Mad1, and E2F-dependent mechanisms

4 , A2059 (1990)

This might include explicit teaching of social norms, practice in real-world settings, and development of self-advocacy skills