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At a glance Drug / alendronate (Fosamax), oral bisphosphonate for osteoporosis Supplement / glutathione, endogenous antioxidant tripeptide (glycine-cysteine-glutamate) Known direct interaction / none reported in peer-reviewed pharmacokinetic studies as of 2025 Primary risk / indirect: oral glutathione taken near alendronate may worsen already-poor bisphosphonate absorption Alendronate fasting bioavailability / approximately 0.6% of oral dose reaches systemic circulation Recommended separation window / minimum 30 minutes before or 2 hours after alendronate dosing IV or liposomal glutathione / no chelation data available

Not sure if glutathione is right for you

Lee, S., & Lee, D

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