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Y250 is located much farther from the disulfide bonds (Cys128-Cys206 in the hinge region between K1 and K2 domains, and Cys211-Cys288, Cys232-Cys271, and Cys260-Cys283 in the K2 domain) than the distances between Y198 and disulfide bonds, Cys149-Cys189 and Cys177-Cys201

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ACC guidelines published in 2024 for lower extremity arterial disease management do not discuss GLP-1 RA as part of management, likely due to the recency of the STRIDE trial findings [45]

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Neuroinflammation Level of Evidence: Moderate preclinical evidence ALC exerts significant anti-neuroinflammatory effects through multiple mechanisms