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The rationale above is mechanism-based community reasoning, not direct combination evidence
Some patients who lose 50+ lbs develop loose skin, more often with older age, higher starting weight, or rapid loss
Similarly, in the combined case-control and cohort study by Wium-Andersen and colleagues, 33 low doses of metformin, DPP-4 inhibitors, GLP-1 analogs, and SGLT2 inhibitors were associated with a lower risk of depression in patients with diabetes compared to non users, with the lowest risk for sodium-glucose transport protein 2 inhibitor users
Akhter J, Quroms G, Pillai K, et al
The stirring process continued for another 12 h at 50 C, after which the mixture was introduced into 10 mL of deionized water while being sonicated
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