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History In ancient and medieval times, known antipyretic agents were compounds contained in white willow bark (a family of chemicals known as salicins, which led to the development of aspirin), and compounds contained in cinchona bark

Although pannexin channels are primarily known for mediating ATP release, some experimental evidence suggests they may also participate in lactate flux under specific non-homeostatic conditions, though this remains speculative and requires further validation [14]

We described similar results in case of 3-PLG-A-GSH without dopamine coupling in the same experimental set-up [24]

& Harris, C