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For neurological applications, the evidence is more preliminary and the extrapolation from rodent to human more uncertain

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Depletion of H1 promotes oncogenic and self-renewing activity within cells due to decompaction of chromatin and gene activation (Torres et al 2016)

Between 1.5% and 15% of the public has a vitamin B12 deficiency, and certain groups are at a higher risk: Older Adults : As we age, our bodies may produce less stomach acid, which is necessary to absorb B12 from food