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If weight loss stalls for three or more weeks despite adherence, a dose increase or a review of nutritional intake may be warranted

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Also, the adverse cardiovascular safety in clinical trials before 2008 was evaluated based on populations that were not necessarily at high risk of cardiovascular disease and the follow-up duration was relatively short (usually less than 12 months)

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GLP-1 additionally exerts various effects outside the pancreas, including regulation of food intake and appetite (12), inhibition of gastrointestinal motility and secretion (13) and a cardioprotective effect (14,15)