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by Dr Philippa Vincent, MRCGP Allergies, blood and immune system Sickle cell disease Sickle cell disease (SCD) is a serious, inherited condition affecting the blood and various organs in the body

Here are several tests I analyze routinely for functional B12 deficiencies

A comprehensive bariatric blood panel, as recommended by BOMSS, usually includes: Full blood count (FBC) to assess for anaemia Serum ferritin and iron studies Vitamin B12 and folate levels Vitamin D (25-hydroxyvitamin D) and parathyroid hormone (PTH) Calcium, phosphate, and magnesium Zinc and selenium Copper particularly in patients with symptoms or poor dietary intake, or where deficiency is clinically suspected Liver function tests Thyroid function tests if clinically indicated Vitamin A in symptomatic patients or those at increased risk Bone health is another important long-term consideration

Langan, R

MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)