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published in Frontiers in Physiology confirmed that BPC-157 dose- and time-dependently increased GHR expression in isolated rat Achilles tendon fibroblasts at both mRNA and protein level, and that GH added to BPC-157-treated fibroblasts produced significant, dose-dependent increases in cell proliferation establishing GHR upregulation as a specific molecular mechanism through which BPC-157 enhances local tissue sensitivity to growth hormone signalling

This mechanistic distinction is why some researchers investigate both compounds simultaneously the theory being that BPC-157 addresses what happens at the site of tissue damage while TB-500 addresses how the body mobilizes repair resources to that site

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