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Furthermore, these pathways contribute to the attenuation of chronic low-grade inflammation and oxidative stress, the enhancement of insulin sensitivity and substrate delivery, as well as the priming of satellite cells for repair and hypertrophy, thereby yielding synergistic improvements in both muscle metabolism and vascular functionality (75)
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comparing liraglutide 1.2 mg/day + metformin 1000 mg BID with liraglutide 3 mg/day, the combination therapy was effective in reducing fasting glucose and insulin, HOMA-IR, and LDL cholesterol, while only the high dose of liraglutide resulted in a significant improvement of 120 min during OGTT glucose and insulin levels along with a higher weight loss [63]
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For those with type 2 diabetes, this often means trying metformin first before advancing to a GLP-1
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