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Further, mercury has been shown to directly alter neurotransmitter function by affecting the uptake and release of dopamine, norepinephrine and serotonin, preferentially inhibiting GABA A receptor subtypes and stimulating M 3 muscarinic acetylcholine receptors (Atchison and Hare, 1994

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mediated through MC4R Cardiovascular : Reports of blood pressure changes, particularly with higher doses Erections : Spontaneous erections in male users, particularly during initial dosing Injection site : Reactions common with subcutaneous administration Regulatory warnings : TGA (Australia), EMA, and other agencies have issued warnings about unregulated MT-2 use PT-141 Side Effects# PT-141's side effect profile is better characterized through Phase 3 data: Nausea : Most common adverse event (~40% of patients in trials)

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Gorrieri G, Scudieri P, Caci E, Schiavon M, Tomati V, Sirci F, Napolitano F, Carrella D, Gianotti A, Musante I, et al

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