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This adaptation pattern is why the slow titration schedule exists, and why rushing through dose increases almost always backfires
Based on these observations, large-scale, prospective, multicenter registry studies are warranted to confirm generalizability, particularly in primary care settings, and to provide sufficient power for robust multivariable modeling that can validate the exploratory factors associated with response
Satoh TK, Neulinger MM, Stadler PC, Aoki R, French LE
Lentz, T
For example, specific GLP1R variants are associated with stronger appetite suppression in some individuals, while FTO variants correlate with baseline metabolic flexibility
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