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Mutations in the genes encoding these proteins, as well as their abnormal expression, are associated with the pathogenesis of several diseases, including type 2 diabetes, insulin resistance, cancer, and neurodegenerative disorders
Surgery on the stomach - the organ where intrinsic factor is made - could therefore hike the risk of a deficiency - as may certain diseases such as Crohns and Celiac disease
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Neomorphic oral iron preparations, such as Ferric maltol, have demonstrated improved tolerability and efficacy in patients with inactive inflammatory bowel disease [103, 104]