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One possible alternative is medication that acts simultaneously on several receptors as so-called multifunctional agonists
Lipsa D, Cacho C, Leva P, Barrero-Moreno J, Aguar P (2015) Development of a HPLC-UV method for the simultaneous determination of intracellular glutathione species in human cells
If you take prescription medication for mood disorders or autoimmune diseases, run a drug interaction check or ask your pharmacist before combining these OTC medications
Melatonin should be taken at an appropriate time (too early and the person might fight it and override it