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About one-third of participants lost 20 percent or more. LaValle explains that the 16.6 percent average weight loss seen with the Wegovy pill reflects several factors, including the higher 25 mg dose, the 64-week length of the trial, the diet and activity coaching participants received and the strong biological effects of semaglutide as a GLP-1

Retatrutide onset appears comparable, with most researchers observing initial effects within similar timeframes

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The following chapter examines how these physiological differences translate into psychological and behavioral processes during GLP-1 RA treatment