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The appetite-suppressing effect in the brain appears more durable than the stomach-slowing effect, but the early, very palpable sense that food simply isnt interesting does tend to soften over time

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Patients and clinicians are encouraged to: Report any new neurological or haematological symptoms promptly to a GP, and seek urgent assessment if neurological symptoms are present Discuss nutritional supplementation as part of the initial treatment consultation Refer to a dietitian where dietary intake is significantly restricted or where multiple deficiencies are identified Report suspected adverse drug reactions including any nutritional concerns potentially related to retatrutide via the MHRA Yellow Card scheme (available at yellowcard.mhra.gov.uk) Stay informed as MHRA and NICE guidance evolves following any future licensing decision for retatrutide Proactive nutritional monitoring is a cornerstone of safe, responsible prescribing for any medicine that substantially alters dietary behaviour, and retatrutide should be no exception