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J Appl Toxicol 23(4):263

Serious adverse effects are rare but can include allergic reactions or complications if used improperly or in individuals with certain pre-existing conditions

Many employers manage utilization by implementing: Prior authorization BMI requirements Physician documentation Lifestyle coaching Nutrition programs Step therapy Ongoing clinical reviews These guardrails help ensure medications are prescribed appropriately while helping employers better manage long-term costs

However, the improvements we observed in overall cognition composite of NIH Toolbox with l-theaninecaffeine combination is not surprising given that multiple interventional trials and meta-analyses of such trials have suggested that particularly the combination of l-theanine and caffeine seems to improve a variety of cognitive functions 25,26,27,33,36,37

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