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3-month-old female mice (WT or GCLC-KO) were fed with PLX3397 formulated-chow or control chow for 2 months, and brain samples were collected immediately after the end of the feeding period

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Clinical trial data on Tirzepatide, the most structurally similar approved compound, shows that participants maintaining adequate dietary fat had substantially lower gallbladder event rates than those who eliminated fats in an attempt to accelerate weight loss

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