Furthermore, the administration of exogenous GLP-1 resulted in elevated calcitonin expression in the thyroids of normal (wild-type) mice
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The NF-B pathway is activated by pro-inflammatory factors such as TNF- and IL-6 [24], enhancing transcriptional activity through receptor-mediated downstream signaling cascades, inducing the expression of E3 ubiquitin ligase genes atrogin-1 and MuRF1, thereby driving muscle protein degradation via the UPS [25]
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Niu, Y., Yan, H., Zhong, J., Diao, Z., Li, J., Li, C., Chen, L., Huang, W., Xu, M., Xu, Z., Liang, X., Li, Z., & Liu, D