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Then add escalation, missed-dose, measurement, monitoring, and red-flag context

Factors that can increase the risk of B12 deficiency include being over the age of 75, digestive absorption issues, autoimmune conditions, and certain diets like vegetarianism and veganism

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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke