Noninsulin glucose-lowering agents currently used to treat T2D in the USA include biguanides, sulfonylureas, thiazolidinediones, -glucosidase inhibitors, meglitinides, dipeptidyl peptidase 4 inhibitors (DPP4is), sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide 1 receptor agonists (GLP-1 RAs), GLP-1/glucose-dependent insulinotropic polypeptide (GIP) dual agonists, bile acid sequestrants, dopamine-2 agonists, and amylin mimetics [3]
Comparison of Glucagon-Like Peptide-1 Receptor Agonists and Thiazolidinediones on Treating Nonalcoholic Fatty Liver Disease: A Network Meta-Analysis
The central action of GLP-1 receptor agonists is supported by evidence showing that exenatide and semaglutide reduce the intake of high-calorie foods and alcohol, as well as relapse-like drinking in rodent models
Normal variations that do not require concern A week with no weight loss after several weeks of consistent loss is completely normal
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