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The change in radius of gyration (Rg) of the protein, root mean square deviation (RMSD) and root mean square fluctuations (RMSF) of the drug movement in the active site of the protein has been analyzed with respect to simulation time
Using a human intestinal epithelial platform with functional L-cells, researchers can now directly stimulate the epithelium and measure endogenous GLP-1 and other incretin secretion in a physiologically relevant context enabling mechanistic interrogation of secretion biology upstream of receptors
Both are safe for long term use
Specific safety concerns warrant attention in certain populations
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