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Additionally, experts say those with more severe gastrointestinal diseases, such as gastroparesis and inflammatory bowel disease (IBD), should avoid these medications
Known as Sakel's technique, insulin coma therapy was a common treatment for schizophrenia until the late 1950s when it fell out of fashion (Marks 2018
The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving blood flow, and modulation of dopamine and serotonin systems
409,410 This holds promise for developing novel therapeutic strategies targeting the gut microbiota to manage DPN effectively
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