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TRPM8 agonists activate trigeminal nerve signaling, leading to increased basal tear production

3d) remained unchanged in the C group with large variations among individuals

When to Contact Your Healthcare Provider While nausea is common and usually manageable, you should contact your healthcare provider if: Nausea is severe or persistent Youre vomiting frequently Youre unable to keep down fluids (risk of dehydration) Youre considering stopping your medication Symptoms arent improving with the strategies above Severe vomiting or diarrhea can lead to dehydration, which can cause serious complications including acute kidney injury and heart palpitations

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