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In individuals with well-controlled type 1 diabetes, hyperglucagonaemia may not be evident and may only result from inadequate insulin therapy and/or increased neural activity (reflecting a catabolic stress condition)
In contrast to traditional autoimmune diseases, irAEs are usually not chronic (64)
Traditional herbal medicines and functional foods are believed to ameliorate diabetic syndromes via six notable mechanism of actions including enhanced insulin secretion and sensitivity, glucose uptake by muscle cells and adipose tissues and inhibition of glucose absorption from intestine and glucose production from hepatocytes along with demonstrating anti-inflammatory properties ( Figure 2
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