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It plays a significant role in tissue remodeling, wound healing, and skin regeneration

More relevant for targeting ECD was the study of bloodendothelium interactions, where HUVECs were divided into untreated (quiescent endothelium) and stimulated with phorbol-12-myristate-13-acetate (PMA) to mimic an inflammatory response before whole blood perfusion

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Caspase-3 and PARP cleavage decreased (Pyo et al., 2007)

The severity of colon mucosal damage was evaluated using the colonic mucosal damage index (CMDI) following the criteria outlined by Jiang et al