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FDA Drug Safety Communication

Sports authorities are alert to this trend, and more research will likely emerge in coming years

However, direct evidence for this hypothesis is lacking, and currently, there is no oral GLP-1R agonist with effective blood-brain barrier-penetrating ability

In September 2025, the FDA reported instances of compounded GLP-1 products containing unapproved foreign substances and companies selling drugs to consumers that were falsely labeled for research purposes. A 2024 report also found that many active pharmaceutical ingredients for compounded GLP-1s were imported from unregistered foreign suppliers, raising questions about supply chain oversight