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The original goal of the staple was to get the peptide into the cell, but it turns out the staple can also enhance the binding and enhance the specificity, Keating says

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At the molecular level, it modulates the expression of over 4,000 human genes, roughly 6% of the genome, according to a 2012 Broad Institute Connectivity Map analysis published by Pickart, Campbell, and colleagues

This is one reason Dihexa is often categorized among neuropharmacology research compounds and molecular neuroscience tools rather than simple peptides in the traditional sense