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The regulatory effect of GPX8 on Ca 2+ may be related to the inositol 1,4,5-triphosphate receptor (IP3R) effect, and the transmembrane domain (TMD) of GPX8 is thought to play a key role in the regulation of Ca 2+ signaling (Yoboue et al., 2017)
Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics
The widely cited "500 dalton rule" for skin penetration suggests molecules near or above that threshold struggle to cross intact stratum corneum, and hydrophilicity makes it worse
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