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Discuss with your healthcare provider whether baseline bone density testing (DXA scan) is appropriate before starting tirzepatide, particularly if you are a woman over 65, a man over 70, postmenopausal with risk factors, have a history of fractures, or have multiple risk factors

Activation of the PPAR pathway negatively affects fat formation by downregulating the expression of genes associated with new fat formation

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Randomization was conducted using an interactive web response system, assigning participants in a 6:1 ratio to one of several treatment arms: once-weekly subcutaneous Cagrilintide administered in doses of 0.3, 0.6, 1.2, 2.4, or 4.5 mg, once-daily liraglutide 3.0 mg, or a volume-matched placebo

The most likelycause is insufficient strength training