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Probably due to the binding preference of APAP to the active site of each P450 isomer, it is oxidized via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)
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Kaufmann et al., 2009)
Nat Metab 5(12):20472061
Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men
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