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We think the protective effects of GLP-1s are probably multifactorial, says Cindy Lin, resident physician at Case Western Reserve and co-author of the June ASCO study
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The post-antibiotic gut is an unstable environment where Akkermansia introduction can backfire
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Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain ( As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels ( via GH upregulation
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