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Ovulation Induction Single-Dose LH Surge Triggering Research by Ferr-Dolcet and colleagues confirmed that a single gonadorelin administration stimulates ovulation in research models via a transient but potent LH surge demonstrating that the peri-ovulatory follicle, when primed by preceding oestradiol exposure, undergoes high-affinity GnRHR engagement with a single bolus of native GnRH sufficient to trigger the ovulatory cascade providing a mechanistically precise model for studying ovulation induction without the prolonged receptor occupancy of superagonist analogues

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Some people experience reduced effectiveness over time , but this is related to metabolic adaptation and dose adequacy, not injection timing

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