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In KCs, SIRT1 deacetylates the NF-B p65 subunit, inhibiting its transcriptional activity and reducing the expression of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6

Its primary function is to stimulate cell proliferation and lean muscle mass development, making it a valuable tool in research focused on muscle regeneration, tissue repair, and recovery

220 In animal studies, curcumin decreases MDA levels, enhances catalase and SOD activity, and reduces lipid peroxidation

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