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Following the rate determining formation of 8-enolate , this intermediate shows only marginal stabilization over the corresponding transition state and evolves to 8-B4 in a barrierless step

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It is believed that it enhances the target-derived neuroprotection of Ts65Dn basal forebrain cholinergic neurons (BFCNs), which typically begin to atrophy at six months of age due to the impaired retrograde transport of nerve growth factor (NGF) [108]