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However, there remains a lack of validated tools to quantify the changes in PVS

These injections are a generic form of FDA-approved medications that were originally developed to help manage and control Type 2 Diabetes

Positron emission tomography has demonstrated reduced availability of dopaminergic D2/3 receptors in individuals with obesity compared with controls, due to a primary receptor deficiency or secondary downregulation of the receptor [44]

At 104 weeks (2 years), patients in this subgroup reached 30.3% average weight loss confirming that retatrutide doesn't plateau at the primary endpoint and continues to improve with extended treatment