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Why GLP-1 (semaglutide or tirzepatide) Might Be Particularly Relevant in Older Adults Cardiometabolic protection Large cardiovascular outcome trials (e.g., SELECT , SUSTAIN-6 ) show semaglutide reduces major adverse cardiovascular events (MACE), and subgroup analyses suggest these benefits extend to older patients

GLP-1 The 'that's enough' signal

Its impact on quality of life, however, can be disproportionately severe compared to its frequency

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Studies examining body composition changes during GLP-1 therapy, including the STEP trials (semaglutide) and SURMOUNT-1 (tirzepatide), have demonstrated that approximately 2540% of total weight lost may come from lean body mass, including skeletal muscle, rather than exclusively from fat mass