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In a model mimicking severe nephritis, which is essentially 100 percent lethal to the kidneys in humans and deadly to the mouse model, with treatment there was instead an 80 percent survival of the mice

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Neurons, astrocytes, and oligodendrocytes all express it, and IGF-1 signaling has documented roles in neurogenesis, synaptogenesis, myelination, and neuronal survival

This imbalance leads to melanin overproduction, dark spots, uneven tone, and premature wrinkles

You can expect hematologic markers like hemoglobin to move toward normal within a few weeks to a few months depending on severity and replacement schedule