Tirzepatide In a retrospective study of 51 T1D people with obesity, tirzepatide was associated with 8.5% mean Weight loss, 0.9% HbA1c reduction, and a 31.6% decrease in daily insulin dose over 8 months, with no increase in hypoglycemia
doi.org/10.1111/dom.15728 4 Tinsley GM, Nadolsky S
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Both agents have demonstrated generally favourable safety profiles in clinical trials, though Retatrutides long-term safety data is still being collected through ongoing clinical trials
With that regulatory brake reduced, IGF-1 LR3 interacts with IGF-1 receptors more directly and for a longer duration, which is why research protocols report a half-life of roughly 2030 hours, compared to native IGF-1s 1215 hours