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For instance, ROS-mediated modification of KEAP1 precipitates oxeiptosis, while ROS-induced DNA damage initiates parthanatos [74, 75]

Moreover, ERK5 inhibitors can induce the paradoxical activation of ERK5 as a consequence of its nuclear translocation and the transactivation of downstream targets [40]

The presence of Ala88 in VP1 of wt PV2 compared with Tyr75 at this position in the CVB3-CP17 structure avoids a steric clash that would otherwise disrupt the orientation of the compound in the wt PV2-CP17 complex (Fig

The expected increase of m / z was only observed in the matrix-assisted laser desorption ionization (MALDI) spectra of the wild-type enzyme, in line with an S -glutathionylation at C13 (Extended Data Fig

Lysine, though a weaker nucleophile than cysteine or histidine, reacts with anhydrides, imidates, and aldehydes (forming Schiff bases reducible to stable secondary amines), making it a useful handle for chemical labeling