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Data search PubMed searches were performed using relevant terms, including GLP-1, GLP-1 receptor agonists, Exenatide BID, Lixisenatide, Liraglutide, Albiglutide, Dulaglutide, Exenatide LAR, heart rate, and pulse rate

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Where AOD 9604 targets fat cells directly, tirzepatide works through the incretin system, a network of hormones that regulate appetite, digestion, and insulin secretion from the gut level upward

Short-acting GLP-1 RAs, exenatide and lixisenatide, are associated with a transient (112 h) mean placebo- and baseline-adjusted 24-h HR increase of 13 beats per minute (bpm)