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KEMU, p = 0.025

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R When the methylation cycle is impaired (MTHFR variants, B12/folate deficiency, BH4 depletion), SAH accumulates and inhibits COMT, HNMT, and other methyltransferases simultaneously

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Research involving Glutathione commonly investigates its interaction with: Cellular oxidative-stress pathways Reactive oxygen species (ROS)-related mechanisms Antioxidant-support pathways involving compounds such as Vitamin C and Vitamin E Cellular detoxification and antioxidant-support signaling Cellular-resilience and physiological-maintenance pathways Because of its broad antioxidant research profile, Glutathione is frequently investigated in oxidative-stress, metabolic-support, healthy-aging, and physiological-resilience research models