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Diabetic neuropathy mainly comprises distal symmetric polyneuropathy, leading to sensory loss, pain, and motor dysfunction, and can result in diabetic foot ulcers requiring lower-limb amputations

FIGURE 1 COMPOSITION OF THE CYTOSOLIC LABILE IRON POOL From a conceptual standpoint, the cytosol must contain a kinetically labile, metabolically accessible pool of iron so that iron can be distributed to its various sites of utilization, transport, or storage (reviewed in Hider and Kong, 2013)

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[146] [159] The effects of amphetamine on gene regulation are both dose- and route-dependent

Lee C, Longo VD