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History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy
Fans of the reclassification say that allowing compounding pharmacies to make these drugs will allow some degree of FDA oversight, and will therefore protect customers some of whom may already be injecting themselves with unproven peptides that are not intended for human use
Ease of use: PT-141 nasal spray is considerably easier to use and administer, as it can be conveniently sprayed in the nostrils
Most individuals transition to a maintenance schedule of one injection every 1-3 months, depending on their specific needs and how well they maintain B12 levels through diet and oral supplements
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