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6.3 Clinical applications in cardiovascular disease prevention Recent American College of Cardiology/American Heart Association guidelines advocate for the use of GLP-1RAs in patients with T2DM at high risk of atherosclerotic cardiovascular disease (ASCVD), irrespective of well-controlled glucose levels, based on the clinical trials mandated by FDA-issued industry guidelines in December 2008 to assess the cardiovascular effects of new diabetic therapies (247)
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Mitochondrial malate dehydrogenase (MDH2) converts 2-oxoglutarate to 2-HG while alcohol dehydrogenase iron containing 1 (encoded by the ADHFE1 gene) converts GHB to 2-HG and succinic semialdehyde (SSA)
(1999) Ipamorelin Induces Longitudinal Bone Growth in Rats Growth Horm IGF Res
doi: 10.1016/S2213-8587(20)30075-9
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