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14,15 Potential Direct Effects on the Heart Although the systemic indirect effects of GLP-1RAs are well established as the primary drivers of their clinical benefit in HF, emerging preclinical and mechanistic evidence suggests GLP-1RAs may also exert some direct cardioprotective effects, as discussed below
Results for albiglutide were also neutral in the Harmony Outcomes Study, although hospitalization for heart failure was assesed composite with cardiovascular death as a secondary endpoint (67)
But there is a significant difference between the two conditions
The incorporation of carbon fluorinated moieties into the polymer backbone could allow for the codelivery of oxygen and therefore enable the treatment of hypoxic tumors
Epigallocatechin Gallate (EGCG) and miR-126 : In human endothelial cell cultures, EGCGa key flavonoid in green teahas been shown to increase miR-126 expression, a miRNA crucial for angiogenesis and endothelial regeneration
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