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The reclassification does not resolve all scientific questions about these compounds the lack of large-scale human trials remains a real limitation that physicians and patients should take seriously
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A subsequent 2014 paper by Chang and colleagues in Molecules showed that BPC-157, applied at 0.10.5 g/mL in vitro, dose- and time-dependently upregulated growth hormone receptor expression at both mRNA and protein levels in cultured rat Achilles tendon fibroblasts a mechanistic in vitro finding for which numeric fold-changes and p-values are not reported in the abstract
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