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Participants (18 years) with inadequately controlled type 2 diabetes (HbA1c 80-100%) with metformin and with or without sulfonylurea were randomly assigned (1:1) by an interactive web-response system to 20 mg or 10 mg once-weekly semaglutide
Store reconstituted solution at 2-8C and use within 28 days
The scenario where adding phentermine makes the strongest case is this: a patient on maximum tirzepatide dosing for at least 6 months, with a documented weight loss plateau lasting 8 or more weeks, who has optimized diet, exercise, sleep, and stress management, and whose provider has ruled out medical causes for the plateau (thyroid dysfunction, medication interactions, fluid retention)
This happens when digestion slows too much
Outcomes vary widely, and structured protein intake plus resistance training meaningfully changes them only about 14% of people put such a plan in place
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