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In May 2026, Lilly reported that in a late-stage trial of adults with obesity or overweight and at least one weight-related comorbidity, the highest 12 mg dose of retatrutide produced 28.3% average weight loss over 80 weeks, and more than 45% of participants lost 30% or more of their body weight
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Subungual keratoacanthomaa report of four cases and review of the literature
Over time, the body may adapt to this state and compensate by taking in more calories, which can offset weight loss
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