By slowing digestion and signaling fullness to the brain, GLP-1 may play a supporting role in weight management
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Answer: oral semaglutide is the only oral peptide that is FDA-approved with large clinical trials behind it
In populations with added comorbidities, results are lower: TRIUMPH-2 (obesity + diabetes) showed 20.8%, TRIUMPH-3 (obesity + cardiovascular disease) showed 22.6%, and TRANSCEND-T2D-1 (diabetes-specific, 40 weeks) showed 16.8% all consistent with patterns seen across the GLP-1 drug class, where comorbidities reduce achievable weight loss
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